President Donald Trump has signed an Executive Order launching the Genesis Mission, a new national initiative led by the Department of Energy (DOE) to transform American science and innovation through artificial intelligence (AI). The mission aims to strengthen U.S. technological leadership and global competitiveness by leveraging advanced computing.
The Genesis Mission seeks to double the productivity and impact of American science and engineering within ten years. Its objectives include achieving breakthroughs in energy dominance, accelerating scientific discovery, and enhancing national security.
“Throughout history, from the Manhattan Project to the Apollo mission, our nation’s brightest minds and industries have answered the call when their nation needed them,” said U.S. Secretary of Energy Chris Wright. “Today, the United States is calling on them once again. Under President Trump’s leadership, the Genesis Mission will unleash the full power of our National Laboratories, supercomputers, and data resources to ensure that America is the global leader in artificial intelligence and to usher in a new golden era of American discovery.”
This announcement follows President Trump’s previous Executive Order focused on removing barriers to AI leadership in America as well as his America’s AI Action Plan released earlier this year. These directives aim to encourage innovation, reduce reliance on foreign countries for technology, and fully utilize America’s scientific capabilities.
Secretary Wright has appointed Dr. Darío Gil, Under Secretary for Science at DOE, as director of the Genesis Mission. The initiative will involve all 17 DOE National Laboratories along with industry partners and academic institutions in building an integrated discovery platform. This platform will link leading supercomputers, AI systems, quantum technologies, and advanced scientific instruments across the country.
When completed, this system is expected to be one of the most complex and powerful scientific tools ever developed. It will rely on about 40,000 DOE scientists, engineers, technical staff members, as well as private sector innovators.
The Genesis Mission targets three primary challenges:
– Achieving American energy dominance by using AI for advances in nuclear power, fusion research, and modernizing energy grids.
– Advancing discovery science through investment in quantum technologies with support from both government labs and industry partners.
– Enhancing national security by developing advanced AI tools for defense missions—including ensuring nuclear stockpile safety—and creating new materials suited for defense applications.
Dr. Darío Gil stated: “The Genesis Mission marks a defining moment for the next era of American science. We are linking the nation’s most advanced facilities, data, and computing into one closed-loop system to create a scientific instrument for the ages, an engine for discovery that doubles R&D productivity and solves challenges once thought impossible.”
Brandon Williams, Administrator of the National Nuclear Security Administration (NNSA), commented: “The Genesis Mission represents the next great chapter and an unparalleled opportunity for America’s scientific and national security leadership.
Building on decades of innovation and collaboration across our national laboratories, NNSA will leverage AI, quantum computing, and advanced data analytics that will strengthen our deterrents and ensure the United States maintains an unmatched strategic edge over our adversaries. Under President Trump’s leadership, this mission will embody the very best of American ingenuity, turning science and innovation into security.”
Dr. John Wagner—Chair of DOE’s National Laboratory Directors’ Council—added: “DOE’s National Laboratories are engines of discovery that keep the United States competitive and secure. The Genesis Mission unlocks the full potential of these institutions by giving our scientists and engineers tools to work at the speed of innovation. Our laboratories have always risen to meet the nation’s greatest challenges, and this initiative ensures we continue that legacy in the age of artificial intelligence.”
